A Philosophical Classic: Determinism, Moral Responsibility, and Truth Claims

Throughout the history of philosophy, certain themes recur regularly. Various philosophers in various eras return again and again to perennial topics.

The relationship between certain types of psychological determinism and ethical responsibility is one example. A typical formulation goes something like this: if an individual is determined, logically and temporally prior to his acting, in a way beyond his control or awareness, then when he acts, he cannot be morally responsible for his action.

This formulation is, of course, one of many, and is often used in introductory philosophy classes to begin a discussion.

A second textbook example looks at the relationship between determinism and truth claims. If an individual is in certain ways determined, what does it mean for that individual to utter, or write, a truth claim? Does his lack of freedom in making assertions affect his belief in his own truth claim? Should it affect our evaluation of his truth claim? Was he able to examine the proposition, and alternative propositions, before expressing it?

A third exemplar is a mixture of the first two. What is the relationship between the ability to be morally responsible and the ability to make truth claims? If both are called into question by determinism, then what is the common element in both?

Such classic investigations can be found in Greek antiquity, in contemporary philosophy, and at many points in between.

Overeager Claims about Self-Replication: Thinly Disguised Speculations about the Origins of Life

A perennial question in the philosophy of science addresses the origin of life. The natural sciences themselves investigate this question, but the philosophy of science ponders both the methods of such investigations and any results.

One aspect of this question is exploring the possibility of self-replicating molecules. Is it possible that there could be a chemical compound which somehow reproduces itself?

This history of science admits of a number of “holy grail” quests, some of which have plausible claims to success, like the search for metallic hydrogen, and others of which have failed spectacularly, like attempts to isolate samples of phlogiston or aether. Other “holy grail” quests include the Grand Unified Theory (GUT) or the possibility of life outside of planet Earth.

Historically, such quests often trigger hasty claims, which must then be retracted. Such is the case with self-replicating molecules.

With barely-suppressed fanfare, an article titled “Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication” appeared in June 2016. The authors wrote of “self-folding” molecules and the “self-assembly” of compounds.

The core motive of such research is the unstated subtext that self-reproducing non-living chemical structures could eventually lead to life.

Living structures reproduce themselves routinely. Non-living structures have never, so far, been observed to reproduce themselves.

The question for the philosophy of science is whether it is possible, even in principle, for a molecule to self-replicate.

The empirical question searches for instances of self-replication. The a priori question asks if such a thing is at all possible.

In any case, the particular publication mentioned above was retracted in October 2017. The article and its retraction both appear in the journal Nature Chemistry, edited by Stuart Cantrill. It was not the first, and will not be the last, overeager announcement of progress toward the discovery of a self-reproducing compound.

More promising than the observational task is the theoretical question. Without examining any particular chemical structure, the philosophy of science can ask what would be required to demonstrate the plausibility of the idea of a self-replicating molecule in general. Which general principles of covalent bonding, of ionic bonding, or of chemical reactions, etc., would indicate that it is at all possible, in principle, for there to be a self-replicating molecule?

It would be a mistake to confidently predict any outcome to this search - such predictions lead to retractions like the one mentioned above, made by Tony Jia, Albert Fahrenbach, Neha Kamat, Katarzyna Adamala, and Jack Szostak.

The fewer triumphalist claims on behalf of self-replicating compounds, the better.